LymphedemaV1, Main, Exploration, bibRecord, 001E86

Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?

Identifieur interne : 001E86 ( Main/Exploration ); précédent : 001E85; suivant : 001E87

Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?

Auteurs : Preeti Subhedar [États-Unis] ; Michelle Stempel [États-Unis] ; Anne Eaton [États-Unis] ; Monica Morrow [États-Unis] ; Mary L. Gemignani [États-Unis]

Source :

Annals of surgical oncology [ 1068-9265 ] ; 2015.

RBID : PMC:4688213

Abstract

Introduction

In this study we sought to determine if adoption of the Z0011 criteria was associated with removal of more SLNs.

Methods

In a retrospective review of a prospective database of breast cancer patients treated at our institution between 2006–2013, we identified 5213 eligible patients who elected to undergo breast-conserving surgery; 2372 were treated pre-Z0011 and 2841 post-Z0011. Clinicopathologic factors were collected, and univariate and multivariate models were fit to identify variables associated with number of SLNs removed.

Results

Median patient age, 60 years, did not differ between groups. Median tumor size was similar in both groups—1.1 (0.05–5.0cm) in the pre-Z0011 group and 1.2 (0.1–5.2cm) in the post-Z0011 group. The mean number of SLNs excised in the pre-Z0011 patients was 2.8 compared to 2.9 in post-Z0011 patients (p=0.01). ≤3 lymph nodes were removed in 1771 (75%) pre-Z0011 patients compared to 2006 (71%) post-Z0011 patients (p=0.01). Factors associated with the removal of more SLNs on multivariate analysis included adoption of ACOSOG Z0011 criteria (p=0.03), young age (p≤0.0001), and large tumor size (p=0.0005). ALND was performed in 379 (16%) patients pre-Z0011 compared to 68 (2%) node-positive post-Z0011 patients (p<0.0001).

Conclusion

Since the adoption of Z0011 criteria, we found significantly fewer patients undergoing ALND for positive SLNs. We noted a significant, slight shift in the removal of ≥4 SLNs. The Z0011 criteria were not associated with a clinically significant increase in the number of SLNs removed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688213

DOI: 10.1245/s10434-015-4698-6
PubMed: 26178759
PubMed Central: 4688213

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?</title>
<author><name sortKey="Subhedar, Preeti" sort="Subhedar, Preeti" uniqKey="Subhedar P" first="Preeti" last="Subhedar">Preeti Subhedar</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stempel, Michelle" sort="Stempel, Michelle" uniqKey="Stempel M" first="Michelle" last="Stempel">Michelle Stempel</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Anne" sort="Eaton, Anne" uniqKey="Eaton A" first="Anne" last="Eaton">Anne Eaton</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Morrow, Monica" sort="Morrow, Monica" uniqKey="Morrow M" first="Monica" last="Morrow">Monica Morrow</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gemignani, Mary L" sort="Gemignani, Mary L" uniqKey="Gemignani M" first="Mary L." last="Gemignani">Mary L. Gemignani</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26178759</idno>
<idno type="pmc">4688213</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688213</idno>
<idno type="RBID">PMC:4688213</idno>
<idno type="doi">10.1245/s10434-015-4698-6</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003986</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003986</idno>
<idno type="wicri:Area/Pmc/Curation">003985</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003985</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001334</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001334</idno>
<idno type="wicri:Area/Ncbi/Merge">007620</idno>
<idno type="wicri:Area/Ncbi/Curation">007620</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007620</idno>
<idno type="wicri:doubleKey">1068-9265:2015:Subhedar P:do:the:acosog</idno>
<idno type="wicri:Area/Main/Merge">001E89</idno>
<idno type="wicri:Area/Main/Curation">001E86</idno>
<idno type="wicri:Area/Main/Exploration">001E86</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?</title>
<author><name sortKey="Subhedar, Preeti" sort="Subhedar, Preeti" uniqKey="Subhedar P" first="Preeti" last="Subhedar">Preeti Subhedar</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stempel, Michelle" sort="Stempel, Michelle" uniqKey="Stempel M" first="Michelle" last="Stempel">Michelle Stempel</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Eaton, Anne" sort="Eaton, Anne" uniqKey="Eaton A" first="Anne" last="Eaton">Anne Eaton</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Morrow, Monica" sort="Morrow, Monica" uniqKey="Morrow M" first="Monica" last="Morrow">Monica Morrow</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gemignani, Mary L" sort="Gemignani, Mary L" uniqKey="Gemignani M" first="Mary L." last="Gemignani">Mary L. Gemignani</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of surgical oncology</title>
<idno type="ISSN">1068-9265</idno>
<idno type="eISSN">1534-4681</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">In this study we sought to determine if adoption of the Z0011 criteria was associated with removal of more SLNs.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In a retrospective review of a prospective database of breast cancer patients treated at our institution between 2006–2013, we identified 5213 eligible patients who elected to undergo breast-conserving surgery; 2372 were treated pre-Z0011 and 2841 post-Z0011. Clinicopathologic factors were collected, and univariate and multivariate models were fit to identify variables associated with number of SLNs removed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Median patient age, 60 years, did not differ between groups. Median tumor size was similar in both groups—1.1 (0.05–5.0cm) in the pre-Z0011 group and 1.2 (0.1–5.2cm) in the post-Z0011 group. The mean number of SLNs excised in the pre-Z0011 patients was 2.8 compared to 2.9 in post-Z0011 patients (p=0.01). ≤3 lymph nodes were removed in 1771 (75%) pre-Z0011 patients compared to 2006 (71%) post-Z0011 patients (p=0.01). Factors associated with the removal of more SLNs on multivariate analysis included adoption of ACOSOG Z0011 criteria (p=0.03), young age (p≤0.0001), and large tumor size (p=0.0005). ALND was performed in 379 (16%) patients pre-Z0011 compared to 68 (2%) node-positive post-Z0011 patients (p<0.0001).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Since the adoption of Z0011 criteria, we found significantly fewer patients undergoing ALND for positive SLNs. We noted a significant, slight shift in the removal of ≥4 SLNs. The Z0011 criteria were not associated with a clinically significant increase in the number of SLNs removed.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Subhedar, Preeti" sort="Subhedar, Preeti" uniqKey="Subhedar P" first="Preeti" last="Subhedar">Preeti Subhedar</name>
</region>
<name sortKey="Eaton, Anne" sort="Eaton, Anne" uniqKey="Eaton A" first="Anne" last="Eaton">Anne Eaton</name>
<name sortKey="Gemignani, Mary L" sort="Gemignani, Mary L" uniqKey="Gemignani M" first="Mary L." last="Gemignani">Mary L. Gemignani</name>
<name sortKey="Morrow, Monica" sort="Morrow, Monica" uniqKey="Morrow M" first="Monica" last="Morrow">Monica Morrow</name>
<name sortKey="Stempel, Michelle" sort="Stempel, Michelle" uniqKey="Stempel M" first="Michelle" last="Stempel">Michelle Stempel</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E86 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E86 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4688213
   |texte=   Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26178759" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?

Do the ACOSOG Z0011 Criteria Affect the Number of Sentinel Lymph Nodes Removed?

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.